Understanding Down Syndrome: Clinical Manifestations and Characteristics

What are the common clinical manifestations associated with Down syndrome?

a. Flat nasal bridge
b. Early-onset dementia
c. Hyperplastic mandible
d. Separated sagittal suture
e. High, arched, narrow palate


The appropriate clinical manifestations for Down syndrome include a flat nasal bridge, hyperplastic mandible, and high, arched, narrow palate.

Down syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. This condition is characterized by a variety of clinical manifestations that can affect physical and cognitive functioning.

The appropriate clinical manifestations for Down syndrome are:

  • Flat nasal bridge: Individuals with Down syndrome often have a flat nasal bridge, where the bridge of the nose appears flatter than usual.
  • Hyperplastic mandible: Some individuals with Down syndrome may have a hyperplastic mandible, which refers to an enlarged or protruding lower jaw.
  • High, arched, narrow palate: The shape of the palate in individuals with Down syndrome is typically high, arched, and narrow.

These physical characteristics are commonly observed in individuals with Down syndrome and can help in the diagnosis and management of the condition. It's important for healthcare professionals and caregivers to be aware of these clinical manifestations to provide appropriate care and support to individuals with Down syndrome.

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