Interesting Ways to Describe Fatigue

In the sentence, 'My sister is very tired.', the words 'very tired' describe the physical state of the sister. To make the sentence more interesting, the words 'very tired' could be replaced with the word 'exhausted' or 'drowsy'. Both these words mean considerably tired but offer a more intense or dramatic sense of fatigue. Here is how to use these words: 'My sister is exhausted.' or 'My sister is drowsy'.

Note that 'cheerful' and 'grumpy' also describe moods or states but they do not convey the same meaning as 'very tired'.